Enzymatic DNA Synthesis (EDS) Market

Enzymatic DNA Synthesis (EDS) Market Report, By Product Type (Oligonucleotides, Gene Fragments, Synthetic Genes, Oligonucleotide Libraries), Application (Research and Development, Therapeutics, Diagnostics, Agriculture, Others), and Regions 2024-2032

Market Brief:

"The enzymatic DNA synthesis market market size reached US$ 278.1 Million in 2023. Looking forward, Reports and Insights expects the market to reach US$ 1,500.8 Million by 2032, exhibiting a growth rate (CAGR) of 20.6% during 2024-2032."

Enzymatic DNA synthesis or EDS is a cutting-edge biotechnological method that leverages enzymes to fabricate DNA strands with remarkable precision. This technique offers advantages such as enhanced accuracy, longer sequences, and reduced error rates compared to traditional chemical methods. The process involves enzymes that facilitate nucleotide addition, ensuring high fidelity and minimal side reactions.

Various enzymatic DNA synthesis technologies are available in the market, including PCR-based methods, template-independent enzymatic synthesis like terminal deoxynucleotidyl transferase, and advanced techniques such as DNA polymerases with novel capabilities. These products empower researchers with more efficient and reliable tools for applications ranging from genetic engineering to synthetic biology.

The global enzymatic DNA synthesis market size has increased significantly and is expected to continue to register a robust revenue growth rate over the forecast period. Revenue growth of the market is driven by rising demand for accurate and longer DNA strands in diverse fields, increased consumption in genetic research, biotechnology, and pharmaceuticals, and expanding services catering to custom sequence design and synthesis further accelerating adoption.

Advancements in enzyme engineering and high-throughput techniques enhance efficiency and reduce costs, and initiatives promoting innovation and collaboration in this sector are contributing to rapid evolution in this field. The various advantages of enzymatic DNA synthesis encompass higher fidelity, scalability, and reduced error rates and these are key factors driving traction of this technique. Comprehensive analysis and insights into market trends provide insights and aid stakeholders in harnessing the full potential of this transformative technology.

Comprehensive analysis provides insights into market evolution and potential. Extensive analysis and insights are available in the report to help businesses make more well-informed decisions in this evolving industry. Also, clarity and understanding of market trends helps companies tailor their products to meet customer demands more effectively. 

Enzymatic DNA Synthesis Market Report Overview: 

The global enzymatic DNA synthesis market research report provides comprehensive insights into driving factors, restraints, opportunities, and trends, with provision of in-depth supporting information, data, and statistics and actionable insights.  

Though covered and provided extensively across the report, the data and information format are simple, yet dynamic in order to ensure ease of reading and understanding, as well as presenting and maximizing leverage and use.

Revenues and market share are provided in detail for previous years in order to showcase the evidence upon which our estimations and forecasts are based.  

Revenue growth rates and differences, as well as comparisons and relatable data are provided to further support all findings. Data points are provided for each year – from historical to end of forecast period – and this format is followed for each segment region and respective countries, as well as sub-segments and others.  

Vital details of major companies in the market are provided in the company profile section of the report. Cover includes financials, recent developments, research & development, strategies, product launches, agreements, expansion, mergers & acquisitions, and others.   

The global enzymatic DNA synthesis market research report is segmented on basis of product type, application, end-user, synthesis method, and regions and countries. Regional segmentation includes North America (United States and Canada); Europe (Germany, United Kingdom, France, Italy, Spain, Russia, Poland, BENELUX, NORDIC, and Rest of Europe); Asia Pacific (China, India, Japan, South Korea, ASEAN, Australia & New Zealand, & Rest of Asia Pacific); Latin America (Brazil, Mexico, Argentina, & Rest of Latin America); Middle East & Africa (Saudi Arabia, South Africa, United Arab Emirates, Egypt, Israel, and Rest of MEA). 

Enzymatic DNA Synthesis Market Research and Insights: 

Global enzymatic DNA synthesis market research is comprehensive and the report provides in-depth details of the various factors, trends, patterns, and scenarios and aspects that have a direct or indirect impact, near-term or far-term on the market and products and services etc. 

Some more detailed insights on the global enzymatic DNA synthesis market provided below: 

Advancements in Enzyme Engineering: Continuous progress in enzyme engineering techniques has led to the development of more efficient and accurate enzymes for DNA synthesis. This results in higher fidelity and reduced error rates, attracting researchers seeking reliable DNA constructs.

Expanding Applications in Research and Industry: EDS finds applications in diverse fields, including genetic engineering, synthetic biology, drug discovery, and diagnostics. The expanding scope of its utility broadens the customer base and increases revenue opportunities.

Rising Demand for Custom DNA Sequences: The growing need for tailored DNA sequences for specific research purposes drives demand for enzymatic synthesis services. Researchers and industries require customized DNA constructs, contributing to revenue growth of the market.

Increasing Investment in Life Sciences Research: Investments in life sciences research have surged, thereby boosting demand for advanced tools like EDS. Market revenue potential is expected to continue to increases significantly on the back of government and private entity funding in scientific exploration.

Shift from Traditional Synthesis Methods: EDS offers advantages over traditional chemical methods, such as higher accuracy, longer sequences, and reduced byproducts. As researchers recognize these benefits, a noticeable shift towards enzymatic synthesis has been observed, and this trend is expected to support revenue growth of the market.

Rapid Technological Innovations: Continuous innovation in enzymatic synthesis techniques, coupled with automation and high-throughput capabilities, accelerates the production process. This leads to increased productivity, shorter turnaround times, and improved revenue margins.

Which Key Factors Are Restraining Growth of the Global Enzymatic DNA Synthesis Market? 

Despite the various positive factors and growth prospects in the global market, some restraints and factors are having negative impacts on revenue growth. Some key factors include:  

High Initial Investment: Adoption of EDS technologies often requires substantial upfront investments in equipment, reagents, and skilled personnel. This financial barrier can deter smaller research labs or startups from entering the market, and can restrain potential revenue growth.

Complexity and Learning Curve: Implementing enzymatic DNA synthesis involves intricate processes and requires specialized training. The learning curve for researchers transitioning from traditional methods can dampen rapid adoption, and slow down market expansion.

Regulatory Challenges: As the market grows, regulatory scrutiny around genetic engineering and DNA synthesis increases in parallel. Stringent regulations and compliance requirements can lead to delays and additional costs, and have a negative impact on revenue growth.

Competition from Traditional Methods: Traditional chemical DNA synthesis methods remain established and cost-effective for shorter sequences. Also, competition from well-established techniques can potentially affect the pace of enzymatic DNA synthesis adoption.

Limited Sequence Lengths: Despite advancements, EDS still has limitations on synthesizing extremely long DNA sequences accurately. This constraint restricts its application in certain research areas and industries.

Perceived Risk of Errors: Although enzymatic synthesis offers higher fidelity, concerns about potential errors in synthesized DNA constructs can make researchers adopt caution towards adopting new methods, and this can impact revenue growth in the short term.

What are Some Opportunities for Leading Players in Enzymatic DNA Synthesis Market? 

Companies operating in the global enzymatic DNA synthesis market can leverage various opportunities and revenue streams to drive growth and profitability. Below are some avenues and insights:  

Custom DNA Sequence Services: Companies can offer tailored DNA sequence design and synthesis services, catering to diverse research needs in industries such as biotechnology, pharmaceuticals, and agriculture. Providing custom solutions can lead to higher-value contracts and recurring revenue streams.

High-Throughput Platforms: Developing automated and high-throughput EDS platforms enables companies to cater to large-scale projects and research initiatives. This can attract partnerships with research institutions and industries involved in genome editing and synthetic biology.

Enzyme Development and Engineering: Focusing on improving existing DNA polymerases and enzymes used in synthesis can create a competitive edge. Companies that innovate in enzyme engineering to enhance fidelity, speed, and accuracy can capture a significant market share.

Synthetic Biology Tools: Companies can provide tools and kits for synthetic biology applications, such as gene assembly, pathway engineering, and protein expression. Offering comprehensive solutions to researchers in this rapidly growing field can lead to consistent revenue growth.

Collaborative Research Initiatives: Collaborating with academic institutions and research organizations can not only advance the technology but also create revenue streams through joint projects, licensing agreements, and co-development of enzymatic synthesis technologies.

Education and Training Services: Developing training programs, workshops, and educational resources for researchers looking to adopt EDS can generate revenue while driving wider adoption of the technology.

By strategically capitalizing on these opportunities, companies operating in the global enzymatic DNA synthesis market can diversify revenue streams, strengthen market presence, and contribute to expansion and advancements in the field. 

Region-wise Analysis of Global Enzymatic DNA Synthesis Market

As per regional analysis of the enzymatic DNA synthesis market, most prominent markets are North America, Europe, and Asia-Pacific. North America, with its robust biotech and pharmaceutical sectors, registers significantly higher demand for accurate DNA constructs. High focus on synthetic biology and genetic research is driving adoption in Europe, while increasing research investments and expanding life sciences industries contribute significantly to Asia-Pacific market revenue growth. Preferences are shaped by regional developments, with high-throughput solutions being in demand in North America, emphasis on enzyme engineering advancements ranking high in Europe, and exploring cost-effective yet precise DNA synthesis methods being the norm in Asia-Pacific. These regions display varying potentials for product sales and demand based on their distinct research landscapes. 

Why is US the Largest Market for Global Enzymatic DNA Synthesis? 

The United States accounts for largest market share in the global enzymatic DNA synthesis market, primarily due to its thriving research ecosystem and dynamic biotechnology landscape. With a rich network of esteemed research institutions, universities, and biotech companies, there is a substantially high demand for accurate DNA constructs across fields such as genetics, drug discovery, and synthetic biology.

Also, significant investments in the biotech and life sciences sectors in the country supports research and development efforts in advanced DNA synthesis technologies, attracting both domestic and international stakeholders. In addition, dominance in terms of the pharmaceutical industry's reliance on DNA synthesis for drug development, personalized medicine, and therapeutic research is expected to continue to support revenue growth of the US market. Innovation and entrepreneurship trends also drive rapid adoption of cutting-edge techniques, with EDS offering distinct advantages over traditional methods.

Furthermore, a well-defined regulatory framework in the US for genetic engineering and DNA synthesis provides clarity and supports an environment conducive to research and commercial applications. Collaborations between academia, research institutions, and industry accelerates technology development and market growth. Moreover, rising demand for high-throughput DNA synthesis in projects such as genome editing and synthetic biology aligns with the accurate and scalable nature of enzymatic methods, thereby solidifying the prominent position of the US in this crucial market segment.

Which Key Trends Will Drive Enzymatic DNA Synthesis Demand in Europe? 

Rising emphasis on synthetic biology - the practice of constructing biological systems - will create steady incline in demand for precise DNA constructs in Europe. Synthesis accuracy and adaptability of enzymatic DNA aligns perfectly with the requirements of this field, making it a prime candidate for increased sales. Moreover, Europe's strong tradition of collaborative research, where academic institutions, research centers, and industries combine efforts on innovative projects, will lead to greater adoption and demand as EDS advances genetic research and biotechnology.

Also, as personalized medicine gains prominence across Europe, the need for tailored and accurate DNA constructs for diagnostics and treatment will further drive incline in adoption and sales of enzymatic DNA synthesis techniques. The region's well-established regulatory framework for genetic engineering and biotechnology will provide support for methods that are compliant to these regulations, ensuring safety and ethical considerations and boosting sales growth.

In addition, growing awareness of environmental sustainability will resonate with environmentally-conscious researchers and industries, and drive sales through enzymatic DNA synthesis's potential for reduced waste and environmental impact compared to traditional chemical methods. The rise of startups and small to medium-sized enterprises or SMEs in Europe's biotech sector presents ample opportunities for EDS providers, as these entities seek cost-effective, accurate, and customizable DNA constructs.

Why Investment in China and India is Key to Growth of the Global Enzymatic DNA Synthesis Market: 

Investing in China and India holds significant momentum for growth of the global enzymatic DNA synthesis market, driven by factors unique to these countries. With expansive research sectors spanning biotechnology, pharmaceuticals, and agriculture, both countries offer substantial potential for the adoption of enzymatic DNA synthesis. Increasing investments in research and development in China and India serve as catalysts for innovation and the integration of cutting-edge technologies like enzymatic DNA synthesis. Notably, ambitious genomic research initiatives in these countries find a crucial partner in EDS, providing the precise DNA constructs essential for unraveling the genetic underpinnings of diseases and traits.

Both China and India have rapidly growing biotechnology industries that are majorly dependent on DNA synthesis for various applications, ranging from gene editing to synthetic biology. This rising demand further highlights the need for investments in enzymatic synthesis technologies. As personalized medicine gains traction, capability of enzymatic DNA synthesis to produce tailored DNA constructs for diagnostics and treatment aligns seamlessly with the healthcare trends in these countries.

Moreover, impacts of investments extend to the cost-effectiveness and scalability of this technology,  and these are essential attributes for countries known for their manufacturing prowess. Collaborative opportunities between local research institutions and international enzymatic DNA synthesis companies also hold major potential to accelerate technology adoption and development. By fostering innovation in startups and small and medium-sized enterprises, investment injects dynamism into the market while promoting global competitiveness.

Hence, directing investments towards China and India not only capitalizes on their research potential and growing biotech sectors, but also nurtures innovation, accelerates technology integration, and fortifies the global enzymatic DNA synthesis market against evolving research demands.

What is the Outlook on Enzymatic DNA Synthesis in Middle East and Africa? 

The outlook for EDS market in the Middle East & Africa (MEA) is characterized by a balance of opportunities and challenges. The region, though in the nascent stages of biotechnology and life sciences, holds promise for enzymatic DNA synthesis adoption. Growing research investments in healthcare and agriculture creates a conducive environment for the adoption of advanced technologies. The region's healthcare sector is advancing, with personalized medicine and genetic diagnostics gaining traction, providing opportunities for enzymatic DNA synthesis to contribute to accurate and tailored DNA constructs.

Similarly, the agricultural industry can benefit from genetically modified crops developed using enzymatic DNA synthesis methods, contributing to food security. Collaborations between local institutions and international partners could expedite the integration of enzymatic DNA synthesis. Also, emergence of biotech startups signals a growing interest in biotechnology applications, possibly making these startups important adopters of the technology.

Moreover, challenges in terms of infrastructure, expertise, and regulatory alignment in countries in the region are key concerns. Building the necessary infrastructure and cultivating expertise for advanced biotechnological techniques like EDS will be a gradual process, potentially hindered by limited resources and skilled personnel. Harmonizing regulatory frameworks across MEA countries is crucial to ensure the responsible and ethical use of enzymatic DNA synthesis. Educating researchers, industries personnel, and policymakers about the technology's benefits is essential to overcome skepticism. Economic considerations could also affect adoption, as initial costs might pose challenges in resource-constrained settings.

Which Latin American Countries will be at the Forefront of Growth for Companies in Enzymatic DNA Synthesis Market? 

In Latin America, countries offering most lucrative growth opportunities for players operating in the enzymatic DNA synthesis market are Brazil, Mexico, and Argentina. Brazil, as the region's largest economy, boasts a thriving biotechnology sector and a robust research environment. With its significant healthcare and agriculture industries, Brazil presents substantial avenues for the application of EDS technologies. Mexico, known for its growing research and biotech ecosystem, emerges as another attractive market. Endeavors in genetic research, pharmaceutical development, and agricultural innovation in the country provide a conducive landscape for the adoption of enzymatic DNA synthesis.

Argentina, with scientific research and innovation, holds potential market opportunities. High focus on agricultural biotechnology and medical research aligns with the capabilities of enzymatic DNA synthesis, paving the way for potential growth of the market in this country.

Chile's dedication to biotechnology and genomics is evident in its research institutes and universities, offering potential for the utilization of DNA synthesis technologies in areas such as mining, agriculture, and environmental studies. Similarly, Colombia's developing biotech sector, coupled with increasing research investments, positions it as a market with diverse applications ranging from healthcare to agriculture.

Peru's growing biotech industry, combined with initiatives spanning agriculture, conservation, and health, creates demand for DNA synthesis products. Collectively, expanding economies, research capabilities, and focus on biotechnology place importance on these countries in terms of potential as key growth markets in Latin America.

Leading Enzymatic DNA Synthesis Companies & Competitive Landscape: 

The global enzymatic DNA synthesis market features a competitive landscape shaped by technological innovation, research collaborations, and the pursuit of enhanced accuracy and efficiency. Key players in this market are driving advancements in enzymatic DNA synthesis methods, catering to diverse research needs in biotechnology, pharmaceuticals, and genetic engineering.

Companies are focused on deployment of proprietary semiconductor-based synthesis platforms that enable high-throughput and cost-effective DNA production. Companies also focus on customizable DNA constructs for various applications to secure a robust position among market leaders. Also, companies are gaining specialization in automated DNA synthesis for complex genetic engineering, and some adopt mergers with other companies to strengthen market position by leveraging expertise.

Besides offering comprehensive services and entering into collaborations with research centers and researchers to maintain a competitive edge, companies are adopting strategies such as entering into CRISPR genome engineering and synthetic biology, and utilizing EDS to support genome editing applications. Some are also developing technologically advanced devices, systems, and solutions such as benchtop DNA printer, which enables rapid synthesis of genes, pathways, and genomes, and others are leveraging benefits of innovation, automation, and scalability. In addition, collaborations with research institutions, partnerships, and alliances is resulting in offering solutions that accelerate scientific breakthroughs and biotechnological advancements, and this further enhances market position of such companies.

Recent Developments:

  • On 3 July 2023, Camena Bioscience, which is a synthetic biology firm supplying genes to the pharmaceutical and biotechnology sectors, disclosed the successful closure of a USD 10 million Series A funding round, primarily spearheaded by Mercia. The fresh capital injection will facilitate expansion of its operations and the ongoing advancement of its groundbreaking DNA synthesis platform - gSynth. Camena stands as the pioneer in delivering this distinct and remarkably precise enzyme-based DNA synthesis technology, having already established commercial partnerships with prominent consumers of synthetic genes.
  • In July 2023, NunaBio, which is a spinoff from Newcastle University in the United Kingdom, announced progression in terms of efforts to bring to market an innovative enzymatic DNA synthesis technology, with diverse applications, including diagnostics. The company has secured three grants in the UK to advance its technology and also successfully raised USD 2.5 million in a seed funding round. In addition, NunaBio has been actively working on advancing an enzymatic DNA synthesis technology, and this is also an active pursuit of other companies such as DNA Script, Molecular Assemblies, Ansa Biotechnologies, Twist Bioscience, and Evonetix.
  • In June 2023, researchers at the Perelman School of Medicine at the University of Pennsylvania pioneered a novel method for mapping 5-methylcytosine (5mC) DNA markings. These markings play vital roles in gene expression and overall health. This innovative approach enables DNA profiling with minimal sample sizes, preserving sample integrity, making it applicable to liquid biopsies for early cancer detection. Unlike existing methods, it offers precise identification of 5mC without potential confusion with other common DNA markings.
  • On 11 April 2022, Ansa Biotechnologies announced the successful closure of an oversubscribed USD 68 million Series A funding round, led by Northpond Ventures, with participation from new investors such as RA Capital, Blue Water Life Science Advisors, Altitude Life Science Ventures, and others, alongside existing investors, including Mubadala Capital and Humboldt Fund. This brings the company's total private financing to USD 82 million. The funds will expedite the development of Ansa's advanced enzymatic DNA synthesis technology, enhance R&D and manufacturing facilities, and expand its team across various disciplines to support the launch of its DNA synthesis service and high-throughput synthesizers.

Company List:

  • Telesis Bio Inc.
  • Evonetix
  • Ansa Biotechnologies, Inc.
  • Camena Bio
  • GenScript Biotech Corp.
  • Molecular Assemblies
  • DNA Script
  • Touchlight
  • Synbio Technologies
  • Twist Bioscience

Research Scope:

Report Metric

Report Details

Market size available for the years   


Base Year


Forecast Period       


Compound Annual Growth Rate (CAGR)


Segment covered 

Product Type: Oligonucleotides, Gene Fragments, Synthetic Genes, Oligonucleotide Libraries

Application: Research and Development, Therapeutics, Diagnostics, Agriculture, Others

End-user: Biotechnology Companies, Pharmaceutical Companies, Research Institutes, CROs, Academic Institutions

Synthesis Method: PCR-Based DNA Synthesis, Enzymatic Template-Independent DNA Synthesis, Advanced DNA Synthesis Methods

Regions Covered

North America:  The U.S. & Canada

Latin America: Brazil, Mexico, Argentina, & Rest of Latin America

Asia Pacific: China, India, Japan, Australia & New Zealand, ASEAN, & Rest of Asia Pacific

Europe: Germany, The U.K., France, Spain, Italy, Russia, Poland, BENELUX, NORDIC, & Rest of Europe

The Middle East & Africa:  Saudi Arabia, United Arab Emirates, South Africa, Egypt, Israel, and Rest of MEA 

Fastest Growing Market in Europe


Largest Market

North America

Key Players

Telesis Bio Inc; Evonetix; Ansa Biotechnologies, Inc.; Camena Bio; GenScript Biotech Corp.; Molecular Assemblies; DNA Script; Touchlight; Synbio Technologies; and Twist Bioscience

Market Segmentation:

By Product Type:

  • Oligonucleotides
  • Gene Fragments
  • Synthetic Genes
  • Oligonucleotide Libraries


  • Research and Development
  • Therapeutics
  • Diagnostics
  • Agriculture
  • Others


  • Biotechnology Companies
  • Pharmaceutical Companies
  • Research Institutes
  • Contract Research Organizations (CROs)
  • Academic Institutions

Synthesis Method:

  • PCR-Based DNA Synthesis
  • Enzymatic Template-Independent DNA Synthesis
  • Other Advanced Methods

Segmentation By Region:

North America:

  • United States
  • Canada


  • Germany
  • The U.K.
  • France
  • Spain
  • Italy
  • Russia
  • Poland
  • Rest of Europe

Asia Pacific:

  • China
  • Japan
  • India
  • South Korea
  • Australia & New Zealand
  • Rest of Asia Pacific

Latin America:

  • Brazil
  • Mexico
  • Argentina

Middle East & Africa:

  • Saudi Arabia
  • South Africa
  • United Arab Emirates
  • Israel

Frequently Asked Question

What are some primary factors driving growth of the enzymatic DNA synthesis market?

Growth of the enzymatic DNA synthesis market is driven by advancements in enzyme engineering, expanding applications in genetic research and biotechnology, rising demand for customized DNA sequences, increased investments in life sciences research, and shift from traditional synthesis methods.

How does enzymatic DNA synthesis differ from traditional chemical methods?

Enzymatic DNA synthesis relies on specialized enzymes to accurately construct DNA strands, offering benefits such as higher fidelity, longer sequences, reduced error rates, and scalability. In contrast, traditional chemical methods involve chemical reactions to build DNA strands, often with limitations in accuracy and sequence length.

What advantages does enzymatic DNA synthesis offer in terms of research and development?

Enzymatic DNA synthesis provides researchers with accurate and customizable DNA constructs, enabling advancements in genetic engineering, synthetic biology, drug discovery, and diagnostics. The technology's precision, scalability, and reduced error rates contribute to more reliable research outcomes.

How does regional analysis impact enzymatic DNA synthesis adoption?

Regional analysis highlights key markets such as North America, Europe, Asia-Pacific, Latin America, and the Middle East & Africa. Analysis and outcomes highlights varying trends, preferences, and growth drivers specific to each region, helping companies tailor their strategies to tap into unique opportunities.

What are some key trends driving enzymatic DNA synthesis adoption and sales?

Key trends include emphasis on synthetic biology, increasing research collaborations, personalized medicine applications, supportive regulatory environments, sustainability considerations, rise of biotech startups, and continuous advancements in enzyme engineering techniques. These trends collectively shape the adoption landscape and future market growth scenarios.

Please Fill Your Details

Your personal details will remain secure and confidential. Privacy Policy